adenylate energy pool

The term **adenylate energy pool** does not refer to a molecular entity, gene, protein, or classic drug target but rather to the collective pool of the three adenine nucleotides—ATP, ADP, and AMP—within a biological sample. The "adenylate energy charge" is a metric commonly used to describe the energy status of cells, calculated from the relative levels of these nucleotides: \(\text{AEC} = (\text{[ATP]} + 0.5 \times \text{[ADP]}) / (\text{[ATP]} + \text{[ADP]} + \text{[AMP]})\)[3][4][8]. This measure serves as a widely accepted index of cellular energetic state, reflecting how effectively a cell is balancing energy production and use. While enzymes like **adenylate kinase** act on and regulate these pools, the pool itself is not a molecular structure or target for drugs and cannot be considered a receptor, enzyme, transporter, or conventional therapeutic target[1][2][4]. Thus, it should not be treated as a druggable target or entry in structured databases of molecular targets, and the target entry is incorrect.

Other names

adenylate energy chargeAECadenine nucleotide pooladenine nucleotide energy pool