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Adenylate kinase 3 pseudogene (None)

Target
None
Molecular classification
Pseudogene
01

Overview

Adenylate kinase 3 pseudogene refers to a genomic segment related in sequence to the functional adenylate kinase 3 (AK3) gene, but it is classified as a pseudogene, meaning it is generally considered nonfunctional due to mutations, truncations, or absence of critical coding potential[1][2][5]. Pseudogenes like this may arise from gene duplication or retrotransposition events and lack the ability to produce functional protein[1][5][7]. The functional AK3 gene encodes a mitochondrial enzyme involved in nucleotide metabolism, but the pseudogene does not. Some pseudogenes have emerging roles as regulatory non-coding RNAs influencing gene expression; however, there is no specific evidence that adenylate kinase 3 pseudogene plays such a role in normal physiology or disease[5][7].\n\nNote: ENSG00000270236 specifically maps to a pseudogene, not a canonical enzyme or therapeutic target[2][6][8]. For information on the functional gene, see "Adenylate kinase 3" (AK3), which is a mitochondrial phosphotransferase enzyme[2][4][9].

Other names
AK3PAK3P4AK3P5
02

Mechanism of action

None (no direct drug mechanism, as pseudogene products are nonfunctional)

03

Biological functions

May have regulatory non-coding RNA functions, such as acting as a competitive endogenous RNA (ceRNA) or miRNA decoy in some contextsNo protein-coding or enzymatic activity
04

Disease associations

Other (pseudogenes can be involved in gene regulation and dysregulation, which may impact diseases indirectly, but this is not established for adenylate kinase 3 pseudogene specifically[5][7])

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