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Target intelligence / Profile preview
Adenylate kinase 4 pseudogene 1 (AK4P1)
- Target
- AK4P1
- Molecular classification
- Pseudogene, Long non-coding RNA (lncRNA), Other
01
Overview
Adenylate kinase 4 pseudogene 1 (AK4P1) is a processed pseudogene located on human chromosome 17. It is transcribed into a long non-coding RNA (lncRNA) of 672 bases. Although it does not encode a protein, it influences pancreatic adenocarcinoma pathology by upregulating the expression of its parent gene, adenylate kinase 4 (AK4), contributing to cancer cell viability, resistance to apoptosis, and potentially the tumor microenvironment. Its transcript is elevated in exosomes from the blood of pancreatic cancer patients compared to healthy controls, making it a candidate biomarker for the disease.
- Other names
- AK4 pseudogene 1lncRNA AK4P1
02
Mechanism of action
Not applicable. There are no drugs acting on this pseudogene
03
Biological functions
Post-transcriptional regulation of parental gene (AK4) expressionModulation of cancer cell viability and apoptosis (through upregulation of AK4 in pancreatic adenocarcinoma cells)Intercellular communication via exosomal RNA in cancer microenvironment
04
Disease associations
Cancer (pancreatic adenocarcinoma; association with poor prognosis)Other
05
Safety considerations
None described for therapeutic targeting, as it is not a classical target. The role in cancer biology is still being explored
06
Biomarkers
Elevated exosomal AK4P1 lncRNA in blood may serve as a biomarker for pancreatic adenocarcinoma and poor prognosis
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