Adenylate-uridylate-rich element-containing messenger RNA (ARE-mRNA)

Adenylate-uridylate-rich element-containing messenger RNAs (ARE-mRNAs) are a class of transcripts characterized by conserved AU-rich sequences in their 3' untranslated regions (3' UTRs) that dictate mRNA half-life and translation (Source: PubMed, PMID: 17486126). These elements act as binding sites for ARE-binding proteins (ARE-BPs) like HuR, which stabilizes transcripts, and TTP, which promotes their degradation (Source: UniProt, P26678; P12429). ARE-mRNAs typically encode potent regulatory proteins such as cytokines, growth factors, and proto-oncogenes, making their precise regulation essential for cellular homeostasis (Source: Nature Reviews Molecular Cell Biology). In diseases like cancer and chronic inflammation, the ARE-mediated decay pathway is often subverted, leading to the stabilization of oncogenic or pro-inflammatory transcripts (Source: Journal of Biological Chemistry). Therapeutic targeting of ARE-mRNAs involves small molecules that disrupt the interaction between AREs and stabilizing proteins like HuR, or antisense oligonucleotides designed to modulate specific transcript stability (Source: PMC, PMC4133797).

Other names

AU-rich element-containing mRNAARE-mRNA3' UTR AU-rich elementAdenylate-uridylate-rich element

Modulation of mRNA stability and translation by targeting RNA-protein interactions or using antisense technology