Adenylosuccinate synthetase isozyme 2 (ADSS2)

Adenylosuccinate synthetase isozyme 2 is an enzyme encoded by the ADSS2 gene in humans. It plays a critical role in purine metabolism by catalyzing the first committed step of adenosine monophosphate (AMP) synthesis from inosine monophosphate (IMP), using guanosine triphosphate (GTP) and aspartic acid as substrates. This reaction is essential for both de novo purine nucleotide biosynthesis and salvage pathways, supporting cellular proliferation and energy metabolism. The protein is primarily cytoplasmic, does not contain transmembrane regions or signal peptides, and has several characterized domains related to GTP binding and catalysis typical of ligases forming carbon-nitrogen bonds. Two human isozymes exist; this form is sometimes referred to as the "acidic" or "liver" isozyme due to its tissue distribution[1][4][5]. Defects or dysregulation may be implicated in rare metabolic diseases but are not widely established therapeutic targets at present. If you need structured data extraction for specific fields such as interacting drugs or biomarkers, further targeted research may be required since these entries are currently null based on available sources[3][4].

Other names

Adenylosuccinate synthase 2Adenylosuccinate synthetase, acidic isozymeAdenylosuccinate synthetase, liver isozymeAdSS 2AMPSase 2IMP--aspartate ligase 2L-type adenylosuccinate synthetase