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Adenylate Cyclase (AC)
- Target
- AC
- Molecular classification
- Enzyme, Lyase
01
Overview
Adenylate cyclase (AC) is an enzyme that catalyzes the conversion of ATP to cyclic AMP (cAMP) and pyrophosphate. It plays a central role in signal transduction by producing cAMP, a second messenger that regulates various downstream targets. There are ten membrane-bound isoforms (AC1-AC10) and one soluble isoform (sAC) in mammals, each with unique regulatory properties and tissue distributions. AC activity is regulated by G protein-coupled receptors, calcium, and other factors. Defects in AC signaling have been implicated in various diseases. Although many drugs target upstream GPCRs, direct modulators of AC isoforms are under investigation.
- Other names
- Adenylyl CyclaseAdenyl Cyclase
02
Mechanism of action
Catalyzes the conversion of ATP to cAMP, a second messenger involved in various signaling pathways.
03
Biological functions
Signal transductioncAMP productionRegulation of cellular metabolismRegulation of gene expression
04
Disease associations
Endocrine disordersBacterial infectionsMetabolic disordersCardiac dysfunction
05
Safety considerations
Potential for off-target effects due to multiple isoforms.Disruption of cAMP homeostasis can lead to various physiological consequences.
06
Interacting drugs
Forskolin
2 more in the full profile.
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