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Target intelligence / Profile preview
Adenylyl Cyclase Rv1625c (Cya)
- Target
- Cya
- Molecular classification
- Enzyme, Adenylyl cyclase, Adenylyl cyclase class 4/guanylyl cyclase family
01
Overview
Adenylyl cyclase Rv1625c (Cya) is a membrane-anchored enzyme from Mycobacterium tuberculosis that catalyzes the conversion of ATP to cAMP, a key second messenger involved in cellular signaling. It is considered an evolutionary ancestor of mammalian adenylyl cyclases and serves as a model for studying their structure and function. Rv1625c-generated cAMP is central to Mtb’s ability to sense environmental changes during infection and modulates bacterial growth on cholesterol. Pharmacological modulation of this enzyme could be therapeutically beneficial against tuberculosis infections resistant to conventional treatments.
- Other names
- ATP pyrophosphate-lyaseAdenylate cyclaseMembrane-anchored adenylyl cyclase Cya
02
Mechanism of action
Activation increases cAMP levels; Inhibition reduces cAMP levels
03
Biological functions
cAMP synthesisSignal transductionRegulation of cholesterol metabolism
04
Disease associations
InfectionTuberculosis
05
Safety considerations
Potential for off-target effects due to homology with mammalian adenylyl cyclasesDrug resistance may develop
06
Interacting drugs
V-59
1 more in the full profile.
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