Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Adenylyl cyclase type 6 (AC6)
- Target
- AC6
- Molecular classification
- Enzyme, Adenylyl Cyclase
01
Overview
Adenylyl cyclase type 6 (AC6) is a membrane-associated enzyme that catalyzes the conversion of ATP to cyclic adenosine monophosphate (cAMP), a critical second messenger involved in numerous cellular signaling pathways. AC6 is part of the adenylyl cyclase family, which plays essential roles in transmembrane signaling and is regulated by G protein-coupled receptor activity. It is expressed in heart, vasculature, spinal cord, brain, lungs, kidney, liver, thyroid, and bone. Its activity is regulated by G proteins, calcium, and phosphorylation. Altered expression/activity of ADCY6 are associated with Lethal Congenital Contracture Syndrome 8 (LCCS8), Hypomyelination Neuropathy-Arthrogryposis Syndrome and cancer prognosis. It also plays roles in cardiovascular disease risk and asthma.
- Other names
- ADCY6Adenylate cyclase 6LCCS8
02
Mechanism of action
Adenylyl cyclase type 6 catalyzes the conversion of ATP to cAMP, a second messenger involved in various cellular signaling pathways.
03
Biological functions
Signal transductioncAMP productionRegulation of cardiac functionModulation of airway smooth muscle responsivenessMechanotransduction in bone cells
04
Disease associations
Lethal Congenital Contracture Syndrome 8 (LCCS8)Hypomyelination Neuropathy-Arthrogryposis SyndromeCancerCardiovascular diseaseAsthma
05
Interacting drugs
Forskolin
Beyond the preview
Go deeper on Adenylyl cyclase type 6 (AC6).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Adenylyl cyclase type 6 (AC6).