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Target intelligence / Profile preview
Adherent-Invasive Escherichia coli (AIEC)
- Target
- AIEC
- Molecular classification
- Bacteria, Pathobiont
01
Overview
Adherent-invasive Escherichia coli (AIEC) is a pathotype of E. coli characterized by its ability to adhere to and invade intestinal epithelial cells, as well as survive and replicate within macrophages without inducing host cell death. AIEC is implicated in the pathogenesis of inflammatory bowel diseases (IBD), particularly Crohn’s disease (CD). Potential therapeutic strategies for targeting AIEC include phage therapy, antibiotics, and antiadhesion molecules.
- Other names
- AIEC pathotype
02
Mechanism of action
N/A
03
Biological functions
Adhesion to intestinal epithelial cellsInvasion of intestinal epithelial cellsIntracellular survival and replication in macrophagesBiofilm formationColonization of ileal mucosaInduction of immune response (IgA production)MotilityIron uptake
04
Disease associations
Inflammatory Bowel Disease (IBD)Crohn's Disease (CD)Mucosal barrier dysfunctionGranuloma formationIntestinal fibrosis
05
Safety considerations
Potential for antibiotic resistanceDisruption of gut microbiotaOff-target effects of antiadhesion moleculesSelection of more virulent AIEC strains
06
Interacting drugs
Phage therapy (experimental)
2 more in the full profile.
07
Biomarkers
Presence of AIEC in ileal mucosaLuminal IgA against AIEC surface molecules
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