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Target intelligence / Profile preview
Adhesion G protein-coupled receptor A3 (ADGRA3)
- Target
- ADGRA3
- Molecular classification
- G protein-coupled receptor, Adhesion G protein-coupled receptor, Receptor
01
Overview
Adhesion G protein-coupled receptor A3 (ADGRA3), previously known as GPR125, is a member of the adhesion class of G protein-coupled receptors (GPCRs) characterized by long N-terminal extracellular regions with protein-protein interaction motifs such as Ig-like domains and leucine-rich repeats. ADGRA3 is classified as an orphan receptor since no endogenous ligands have been identified to date. It is highly expressed in the testis and prostate, with evidence suggesting a role in the development of spermatogonia and germ cell function. The receptor has also been implicated as a marker for adult stem and progenitor cells, and its expression is upregulated following brain injury, suggesting possible wider roles in tissue homeostasis and repair. However, direct biological functions and disease associations remain only partially defined, and it is not yet a target for approved therapeutics[1].
- Other names
- GPR125PGR21TEM5LG protein-coupled receptor 125TEM5-likeUNQ556/PRO1113FLJ38547probable G-protein coupled receptor 125
02
Mechanism of action
Not established (as no known ligands or drugs targeting ADGRA3)
03
Biological functions
Signal transductionCell adhesionStem/progenitor cell markerPossible role in spermatogonia and germ cell development
04
Disease associations
Potential role in cancer (tumor angiogenesis and proliferation)Possible involvement in reproductive disordersReported expression/role in brain injury models
05
Safety considerations
None reported (therapeutic use and drug targeting are still unexplored due to orphan status; potential effects on stem cell populations should be considered as a theoretical concern)
06
Interacting drugs
None known (no endogenous or exogenous ligands identified; orphan receptor)
07
Biomarkers
Marker for adult stem and progenitor cells, particularly spermatogonial stem cells
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