Adhesion G protein-coupled receptor E1 (ADGRE1)

Adhesion G protein-coupled receptor E1 (ADGRE1), also known as EMR1, is a member of the adhesion GPCR family characterized by an extended extracellular region containing several EGF-like domains and a seven-transmembrane helix region, linked via a GAIN domain[2][3][4]. It is predominantly expressed on cells of the myeloid lineage: in humans, notably on eosinophils (and minimally on macrophages); in mice, its homolog F4/80 is a widely used marker for tissue-resident macrophages[3][4]. ADGRE1 is involved in cell adhesion, migration, and intercellular signaling, contributing to immune responses, inflammation, and tissue homeostasis[1][2][3][4]. It has roles in mediating macrophage activation and inflammatory signaling, particularly in contexts like metabolic inflammation and chronic immune disorders[1][2]. The receptor is a target for experimental therapies aiming at depleting eosinophils in certain inflammatory and allergic diseases using afucosylated antibodies[3].

Other names

EMR1TM7LN3EGF-like module receptor 1EGF-like module-containing mucin-like hormone receptor-like 1F4/80 (murine)egf-like module containing, mucin-like, hormone receptor-like sequence 1

Antibody-dependent cell-mediated cytotoxicity against EMR1^+^ (eosinophil) cells