Adhesion G protein-coupled receptor E4, pseudogene (ADGRE4P)

Adhesion G protein-coupled receptor E4, pseudogene (ADGRE4P), is a probable pseudogene located on human chromosome 19. It is a member of the EGF-TM7 receptor gene family, which in other species encodes 7-transmembrane adhesion G protein-coupled receptors[2][4][7]. In humans, a frameshift-causing nucleotide deletion disrupts the open reading frame, causing premature translation termination and likely inactivating the gene. No functional protein product is detected in humans; in contrast, functional orthologs exist in non-human primates and rodents[4][7]. As a result, ADGRE4P does not encode a cell-surface receptor or enzyme and is not considered a therapeutic target in humans. It is sometimes referenced in immunology and genomics due to its evolutionary context and family relations but functional implications in human health or disease are unsubstantiated. In summary, ADGRE4P is a nonfunctional pseudogene, not a bona fide protein-coding target in humans[2][4][7][8]. Notes on target validity: - The gene is named as a pseudogene (“Adhesion G protein-coupled receptor E4, pseudogene”), indicating loss of protein-coding function in humans[2][4][7][8]. - Orthologous protein-coding genes (Adgre4) exist and function in mouse and other mammals[4]. - In humans: not a drug target; no drugs, mechanisms, biomarkers, or safety concerns. - Inclusion in lists of GPCRs and disease roles reflects speculative, inferred, or family-level function only. - Query contains possible redundancy with aliases (GPR127, EMR4, etc.), but all refer to the same locus. For future structured data extraction, this entry should be considered non-druggable, non-functional (pseudogene), and not a clinically actionable target in humans.

Other names

EGF-like module receptor 4EGF-like module-containing mucin-like hormone receptor-like 4Putative adhesion G protein-coupled receptor E4PG-protein coupled receptor PGR16G-protein coupled receptor 127EGF-TM7 receptor EMR4FIRE (F4/80-like-receptor)EMR4EMR4PGPR127PGR16

None (no drugs known to target ADGRE4P)[4]