Adhesion G protein-coupled receptor F3 (ADGRF3)

Adhesion G protein-coupled receptor F3 (ADGRF3), also known as GPR113 or PGR23, is a member of the adhesion family of G protein-coupled receptors (GPCRs)—characterized by long extracellular domains containing functional subdomains and a conserved GAIN (GPCR-Autoproteolysis Inducing) domain responsible for autoproteolytic cleavage[2][4][8]. Like other adhesion GPCRs, ADGRF3 cleaves itself during maturation to yield an N-terminal fragment and a membrane-embedded C-terminal fragment; these remain non-covalently associated. ADGRF3 is an orphan receptor (no endogenous ligand is firmly established for its function or pharmacology) and is predicted to participate in G protein-coupled receptor signaling and adenylate cyclase activation[1][6]. It is expressed in several tissues, notably in subsets of taste receptor cells and the olfactory bulb in mice, suggesting a role in sensory or neuropeptide signaling pathways[4]. Disease relevance is emerging but not well established; altered expression is reported in type 2 diabetes and with genetic deletions affecting related pathways, but there are no robust associations with specific human diseases, and to date, it is not a therapeutic or diagnostic biomarker nor a target for approved drugs[4].

Other names

GPR113PGR23hGPCR37G-protein coupled receptor 113G-protein coupled receptor PGR23probable G-protein coupled receptor 113seven transmembrane helix receptor