Molecular Classification
Adhesion G protein-coupled receptor, GPCR, Seven-transmembrane domain protein
Other Names
GPR116
Disease Roles
Pulmonary dysfunctionRenal tubular alkalosisImpaired glucose tolerance

Adhesion G protein-coupled receptor F5 Overview

Adhesion G protein-coupled receptor F5 (ADGRF5), also known as GPR116, is a member of the adhesion GPCR family. It is a transmembrane receptor with diverse physiological roles in multiple tissues and organ systems. It plays a role in lung surfactant regulation, renal acid secretion, metabolic regulation, pancreatic islet function, and immune system regulation.

Mechanism of Action

Tethered agonist activation mode

Biological Functions

Signal transduction
Pulmonary surfactant homeostasis
Renal acid secretion
Glucose metabolism
Insulin sensitivity
Innate immune cell regulation
Pancreatic islet function
Somatostatin release
Islet development

Disease Associations

Pulmonary dysfunction
Renal tubular alkalosis
Impaired glucose tolerance
Reduced insulin sensitivity
Inflammation
Reproductive system dysfunction

Safety Considerations

  • Potential for off-target effects due to broad tissue distribution