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Adhesion G protein-coupled receptor F5 (ADGRF5)
- Target
- ADGRF5
- Molecular classification
- Adhesion G protein-coupled receptor, GPCR, Seven-transmembrane domain protein
01
Overview
Adhesion G protein-coupled receptor F5 (ADGRF5), also known as GPR116, is a member of the adhesion GPCR family. It is a transmembrane receptor with diverse physiological roles in multiple tissues and organ systems. It plays a role in lung surfactant regulation, renal acid secretion, metabolic regulation, pancreatic islet function, and immune system regulation.
- Other names
- GPR116
02
Mechanism of action
Tethered agonist activation mode
03
Biological functions
Signal transductionPulmonary surfactant homeostasisRenal acid secretionGlucose metabolismInsulin sensitivityInnate immune cell regulationPancreatic islet functionSomatostatin releaseIslet development
04
Disease associations
Pulmonary dysfunctionRenal tubular alkalosisImpaired glucose toleranceReduced insulin sensitivityInflammationReproductive system dysfunction
05
Safety considerations
Potential for off-target effects due to broad tissue distribution
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