Adhesion G protein-coupled receptor G2 (ADGRG2)

Adhesion G protein-coupled receptor G2 (ADGRG2), also known as GPR64, is a member of the adhesion family of G protein-coupled receptors predominantly expressed in the male reproductive tract, especially in the epididymis and efferent ducts[2][3][4]. It plays a critical role in regulating fluid reabsorption and maintaining male fertility by mediating signal transduction via G protein pathways (primarily Gs and Gq), affecting the function of downstream effectors such as adenylate cyclase and phospholipase C[2][3]. Mutations in ADGRG2 are implicated in disorders such as congenital bilateral absence of the vas deferens, leading to male infertility[2][3]. Recent structural studies identified steroid hormones, including DHEA, as ligands, providing the basis for ongoing pharmacological research and making ADGRG2 a potential therapeutic target for male reproductive health and related conditions[1].

Other names

G protein-coupled receptor 64GPR64Human epididymis-specific protein 6HE6TM7LN2EDDM6Epididymal protein 6CBAVDX

Agonist binding (e.g., DHEA) activates G protein signaling via Gs and Gq proteins, leading to stimulation of adenylate cyclase or phospholipase C pathways[1][2][3].