Target intelligence / Profile preview

Adhesion Molecule (CAM)

Target: CAM
Molecular classification: Integrin, Cadherin, Selectin, Immunoglobulin Superfamily, Mucin

Overview

Adhesion molecules are cell surface proteins that mediate cell-cell and cell-extracellular matrix interactions. They are critical for tissue architecture, development, immune response, and disease processes. Major families include integrins, cadherins, selectins, and the immunoglobulin superfamily. They are considered therapeutic targets for a variety of diseases.

Other names: Cell Adhesion MoleculeCAMs

Mechanism of action

Modulation of cell-cell and cell-ECM interactions, blocking or enhancing adhesion

Biological functions

Cell adhesionTissue developmentImmune cell traffickingWound healingSynapse formationCell migrationCell-ECM interactionCell-cell interaction

Disease associations

Cancer metastasisAutoimmune disordersRheumatoid arthritisNeurodegenerative diseasesParkinson's diseaseInfectionInflammation

Safety considerations

Potential for off-target effects due to broad expression of some adhesion moleculesRisk of disrupting normal tissue homeostasis or immune functionDevelopment of resistance mechanismsImmunogenicity of therapeutic antibodies targeting adhesion molecules

Interacting drugs

Drugs modulating adhesion molecule activity

Biomarkers

Expression levels of specific adhesion molecules in tissue or serumChanges in adhesion molecule expression correlated with disease progression or treatment response

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