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Adipogenesis-related gene expression
01
Overview
Adipogenesis-related gene expression" refers to the dynamic, coordinated activation and repression of multiple genes during the differentiation of stem cells into adipocytes. This process is governed by a network of transcription factors (notably PPARγ and C/EBP family members), epigenetic regulators (histone modifications, DNA methylation, chromatin remodeling complexes, non-coding RNAs), and signaling pathways[1][2][3]. It is central to the development of adipose tissue and is implicated in metabolic diseases such as obesity and type 2 diabetes, but it does not represent a single therapeutic target[2][5].
- Other names
- Adipogenic gene expressionAdipocyte differentiation-related gene expressionFat cell differentiation gene program
02
Biological functions
Cell differentiation (adipocyte lineage commitment and maturation)Lipid accumulation and metabolismExtracellular matrix remodelingInsulin sensitivity modulation
03
Disease associations
Obesity (due to excessive adipogenesis and adipose tissue expansion)Metabolic syndromeType 2 diabetes mellitus
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