Adiponectin Receptor (AdipoR)

The adiponectin receptor family, primarily AdipoR1 and AdipoR2, mediates the physiological effects of adiponectin. These receptors are crucial for regulating glucose and lipid metabolism, energy homeostasis, insulin sensitivity, and inflammatory responses. They activate AMPK and PPARα pathways, promote fatty acid oxidation and glucose uptake, and possess intrinsic ceramidase activity. They are considered promising therapeutic targets for metabolic diseases such as type II diabetes.

Other names

ADIPOR1ADIPOR2Progestin and adipoQ receptor family memberPAQRPAQR1PAQR2

Agonists bind to AdipoR1 and AdipoR2, activating AMPK and PPARα pathways, promoting fatty acid oxidation and glucose uptake, and hydrolyzing ceramide into sphingosine and fatty acid.