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Adiponectin Receptor 1 (AdipoR1)
- Target
- AdipoR1
- Molecular classification
- Receptor, Progestin and adipoQ receptor (PAQR) family, Seven-transmembrane receptor
01
Overview
Adiponectin receptor 1 (AdipoR1) is a protein that acts as a major cellular receptor for adiponectin, an essential hormone secreted by adipocytes that regulates glucose and lipid metabolism. Upon ligand binding, it activates AMP-activated protein kinase (AMPK) pathways, leading to increased fatty acid oxidation and glucose uptake in cells. Dysfunction or downregulation of the ADIPOR pathway is implicated in metabolic diseases.
- Other names
- PAQR1
02
Mechanism of action
AMPK pathway activation leading to enhanced fatty acid oxidation; promotes increased insulin sensitivity via downstream signaling cascades; may inhibit mTOR pathway through AMPK activation
03
Biological functions
Regulates glucose and lipid metabolismActivates AMPK pathwayRegulates insulin sensitivityMaintains membrane fluidity
04
Disease associations
Type 2 diabetes mellitusObesityCardiovascular diseaseNon-alcoholic steatohepatitis (NASH)Cancer
05
Safety considerations
Dysfunction or downregulation implicated in metabolic diseasesPotential for altered insulin signaling
06
Interacting drugs
Adiponectin
8 more in the full profile.
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