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Target intelligence / Profile preview
Adiponectin Receptor 2 (AdipoR2)
- Target
- AdipoR2
- Molecular classification
- Progestin and adipoQ receptor (PAQR) family, Receptor, Seven transmembrane receptor
01
Overview
AdipoR2 is a cell surface receptor for adiponectin, a hormone secreted by adipocytes that regulates glucose and lipid metabolism. It binds adiponectin and activates downstream signaling pathways including AMPK and PPAR-alpha, promoting fatty acid oxidation, glucose uptake, and improved insulin sensitivity. AdipoR2 also plays a role in maintaining membrane fluidity.
- Other names
- PAQR2ACDCR2
02
Mechanism of action
Upon binding adiponectin, stimulates AMPK and PPAR-alpha pathways to increase fatty acid oxidation, glucose uptake, and improve lipid metabolism.
03
Biological functions
Regulation of glucose metabolismRegulation of lipid metabolismFatty acid oxidationGlucose uptakeInsulin sensitivity enhancementInflammatory response modulationEnergy homeostasisMembrane fluidity maintenance
04
Disease associations
Type 2 diabetes mellitusObesity-related inflammationCardiovascular diseasesNon-alcoholic fatty liver disease (NAFLD)
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