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Target intelligence / Profile preview
Adiponectin Receptor Protein 1 (ADIPOR1)
- Target
- ADIPOR1
- Molecular classification
- Receptor, PAQR family receptor, Seven-transmembrane receptor
01
Overview
Adiponectin Receptor Protein 1 (ADIPOR1) is a key receptor for adiponectin, a hormone secreted by adipocytes. It mediates the metabolic effects of adiponectin, including activation of AMPK pathways, regulation of glucose uptake and fatty acid oxidation, and modulation of lipid metabolism, inflammation, and oxidative stress. Dysregulation of adiponectin signaling through ADIPOR1 is implicated in obesity-related diseases such as type II diabetes mellitus and cardiovascular disease.
- Other names
- PAQR1Progestin and adipoQ receptor family member 1
02
Mechanism of action
Agonist or antagonist binding to the adiponectin receptor, modulating downstream signaling pathways such as AMPK and PPAR-α to regulate glucose metabolism, lipid metabolism, and inflammation.
03
Biological functions
Adiponectin signalingAMPK activationGlucose uptake regulationFatty acid oxidation regulationLipid metabolism modulationInflammation modulationOxidative stress modulationInsulin sensitivity regulation
04
Disease associations
ObesityType II diabetes mellitusCardiovascular diseaseMetabolic syndrome
05
Safety considerations
Potential for off-target effects due to structural similarities with other PAQR family members.Desensitization of the receptor through phosphorylation, requiring strategies to overcome this limitation.Further research is needed to clarify all downstream signalling effects
06
Interacting drugs
Adiponectin
8 more in the full profile.
07
Biomarkers
Adiponectin levelsInsulin sensitivity
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