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Target intelligence / Profile preview
Adiponectin receptor protein 2 (ADIPOR2)
- Target
- ADIPOR2
- Molecular classification
- Progestin and adipoQ receptor (PAQR) family, Receptor, Transmembrane receptor
01
Overview
Adiponectin receptor protein 2 (ADIPOR2) is a receptor for adiponectin, a hormone secreted by adipocytes that regulates glucose and lipid metabolism. It is a seven-transmembrane protein that activates AMPK and PPAR-alpha pathways upon adiponectin binding. ADIPOR2 plays a role in antidiabetic and antiatherogenic processes. It is also involved in maintaining membrane fluidity. Reduced expression is observed in diabetic kidneys.
- Other names
- ACDCR2PAQR2
02
Mechanism of action
Adiponectin binding, AMPK/PPARα activation
03
Biological functions
Adiponectin receptor activityRegulation of glucose metabolismRegulation of lipid metabolismAMPK pathway activationPPAR-alpha pathway activationMaintenance of membrane fluidity
04
Disease associations
Atypical Hemolytic-Uremic SyndromePrediabetes SyndromeMetabolic disease
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