Adipose differentiation-related protein pseudogene

Adipose differentiation-related protein pseudogene (ENSG00000223599) is a non-coding genomic element classified as a pseudogene, related by sequence homology to the ADFP gene encoding ADRP/perilipin-2, a lipid droplet-associated protein[5]. Pseudogenes such as ENSG00000223599 are not expressed as functional proteins and do not carry out the biological activities associated with their protein-coding relatives. The term "adipose differentiation-related protein" typically refers to perilipin-2 (ADRP, adipophilin), a member of the perilipin family that localizes to lipid droplets and regulates neutral lipid storage in adipocytes and other cell types[1][5]. However, the pseudogene with this name is not a molecular target for therapeutic intervention and lacks function, disease relevance, or pharmacological interactions. If structured data or research focus is desired on a true therapeutic target in lipid metabolism, perilipin-2 (ADRP, gene symbol ADFP) should be referenced rather than its pseudogene[5][1]. In summary: ENSG00000223599 refers to a pseudogene, not the active protein ADRP/perilipin-2. It is incorrectly listed as a target, does not encode a receptor/enzyme/transporter, lacks function, alias, or drug interactions, and is not involved in molecular pathways or disease directly. For actual lipid droplet biology, refer to perilipin-2 (ADRP/adipophilin)[5][1].