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Target intelligence / Profile preview
Adipose-secreted signaling protein (ADISSP)
- Target
- ADISSP
- Molecular classification
- Secreted protein, Adipokine
01
Overview
Adipose-secreted signaling protein (ADISSP) is a secreted adipokine, primarily expressed in brown adipose tissue (BAT) and beige adipocytes, and it plays a crucial role in the regulation of white adipose tissue (WAT) thermogenesis and glucose homeostasis[1][5][6]. Its secretion is stimulated by β3-adrenergic activation, and it acts by binding a putative receptor at the adipocyte surface, promoting PKA pathway activation independently of β-adrenergic signaling[1]. Functional studies in mice reveal that ADISSP is necessary for efficient WAT browning, protecting against diet-induced obesity and hyperglycemia. Physiologically, it acts as a bioactive mediator in adipose tissue function and metabolic health. This makes it a promising candidate for therapeutic development targeting obesity and type 2 diabetes, potentially with reduced off-target safety risks due to its restricted expression profile[1][2][3][5][6].
- Other names
- Adipose-secreted signaling proteinADISSPC20orf27FLJ20550hypothetical protein LOC54976UPF0687 protein C20orf27
02
Mechanism of action
Activation of protein kinase A (PKA) pathway in adipocytes
03
Biological functions
Regulation of thermogenesisGlucose homeostasisPositive regulation of non-canonical NF-kappaB signalingPositive regulation of transforming growth factor beta receptor signaling
04
Disease associations
ObesityType 2 diabetesMetabolic diseasesCardiovascular diseases
05
Safety considerations
As a potential therapeutic, main concerns would be off-target metabolic effects, but current data suggests a possibility for low side effects due to tissue-specific expression[2]
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