Adipose tissue-derived mesenchymal stromal cell (AT-MSC)

Adipose tissue-derived mesenchymal stromal cells (AT-MSCs), also commonly referred to as adipose-derived stem cells (ASCs) or adipose-derived mesenchymal stem cells (ADMSCs), are multipotent stromal cells isolated from human adipose tissue, typically collected as lipoaspirate from procedures like liposuction[1][3][4]. These cells can differentiate into various mesenchymal lineages such as adipocytes, chondrocytes, and osteoblasts, and possess immunomodulatory and tissue-regenerative properties, both through direct differentiation and via secretion of paracrine factors[3][4][5]. AT-MSCs display a characteristic phenotype, being positive for markers CD73, CD90, and CD105, while lacking hematopoietic and endothelial markers such as CD34 and CD45[3][4]. Their accessibility, high yield, and proliferative capacity have made AT-MSCs an attractive tool for regenerative medicine and cell therapy, with ongoing clinical research in diverse indications including wound healing, cardiovascular disease, autoimmune disorders, and type 1 diabetes[4][5]. However, as a cell type and not a single molecular target (e.g., receptor, enzyme), they do not fit the definition of a classical therapeutic target, hence are not typically the direct target of small molecules or biologic drugs, but rather are used as therapeutic agents themselves in cell-based therapy[2][3][4]. Note: - This entry is marked is_incorrect: true because "Mesenchymal stromal/stem cells from adipose tissue" is a cell population, not a discrete molecular target such as a receptor, enzyme, or protein. This makes it unsuitable as a conventional molecular therapeutic target according to pharmacological or target-based drug discovery frameworks. - Additional entries such as "interacting_drugs" and "mechanism_of_action" are not applicable: drugs generally do not target these cells per se; instead, the cells are administered as cell therapies, or their secreted factors are studied for effects. - They are highly heterogeneous and encompass several subtypes and preparation protocols.

Other names

Adipose-derived mesenchymal stem cellAdipose-derived stem cellAdipose stromal cellAdipose-derived stromal cellASCADMSCAdMSC