Adipose Tissue Metabolism (N/A)

Adipose tissue metabolism encompasses the biochemical and cellular processes governing energy storage, mobilization, and utilization within adipose (fat) tissue. It involves lipogenesis (fatty acid synthesis and triglyceride storage), lipolysis (triglyceride breakdown into free fatty acids and glycerol), and the secretion of adipokines, which influence whole-body energy balance, glucose homeostasis, and metabolic health. Dysregulation of adipose tissue metabolism is a key factor in the development of obesity, type 2 diabetes, and cardiovascular disease. Adipose tissue also contributes to thermogenesis via specialized cells that express uncoupling protein 1 (UCP1).

Other names

Fat MetabolismAdipocyte MetabolismLipid Metabolism in Adipose TissueAdipose Tissue Remodeling

Varies widely depending on the specific drug. Examples: - Thiazolidinediones: PPARγ agonists, increasing insulin sensitivity in adipose tissue. - Metformin: Primarily reduces hepatic glucose production, but also influences adipose tissue metabolism. - Orlistat: Inhibits pancreatic lipase, reducing dietary fat absorption and indirectly affecting adipose tissue lipid storage. - Beta-adrenergic agonists: Stimulate lipolysis in adipose tissue through activation of beta-adrenergic receptors.