ADP-induced platelet aggregation (N/A)

Adenosine diphosphate (ADP)-induced platelet aggregation refers to the process by which ADP, a nucleotide released from damaged cells and activated platelets, stimulates platelets to clump together—a critical step in hemostasis and thrombosis. This aggregation is mediated through specific ADP receptors on the platelet surface, primarily P2Y1 and P2Y12. Activation of these receptors leads to exposure of glycoprotein IIb/IIIa on the platelet surface, which binds fibrinogen or von Willebrand factor (vWF), cross-linking adjacent platelets into aggregates. ADP binding triggers release of granules containing pro-coagulant molecules—further promoting clot formation. Antagonists targeting P2Y12 (e.g., clopidogrel, prasugrel, ticagrelor) are widely used as antithrombotic agents.

Other names

Adenosine diphosphate-induced platelet aggregationPlatelet aggregation (ADP-induced)

ADP binding to P2Y1 and P2Y12 receptors, leading to platelet activation and aggregation.