ADP-ribosylation factor 6 pseudogene

ADP-ribosylation factor 6 pseudogene (ENSG00000224448) is a genomic locus on chromosome 7 that shares sequence similarity with the protein-coding ARF6 gene, but does not produce a functional protein product[1][2][5]. Pseudogenes such as this are generally remnants of gene duplication or retrotransposition events and do not encode proteins nor participate in cellular pathways. The functional ARF6 protein itself is a member of the Ras superfamily of small GTPases that regulates membrane trafficking, actin cytoskeleton remodeling, endocytosis, membrane recycling, and has roles in cancer, immune signaling, and other processes[1][2][3][4][5]; however, none of these roles are directly attributable to the pseudogene. Key Clarification: If comprehensive drug/functional/cellular/disease information is required, refer instead to the protein-coding gene ADP-ribosylation factor 6 (ARF6, ENSG00000078900), not the pseudogene ENSG00000224448[1][2][3][5]. The pseudogene lacks coding potential, biological function, and relevance as a drug target.

Other names

ARF6 pseudogeneARF6P