ADP-ribosylation factor GTPase-activating protein 1 (ARFGAP1)

ADP-ribosylation factor GTPase-activating protein 1 (ARFGAP1) is an enzyme that functions as a GTPase-activating protein (GAP) for ADP-ribosylation factor 1 (ARF1) and can also act on ARF-like protein Arl1[2][3][4][5]. ARFGAP1 is primarily localized to the Golgi apparatus, where it regulates vesicle trafficking by stimulating the hydrolysis of GTP bound to ARF1, leading to coat protein dissociation from Golgi-derived membranes—an essential step for vesicle fusion with target compartments[2][3][5][6][8]. The activity of ARFGAP1 is modulated positively by phosphoinositides and inhibited by phosphatidylcholine. The protein contains amphipathic lipid packing sensor motifs (ALPS), which enable it to sense membrane curvature and vesicle maturity[3]. Through its function, ARFGAP1 is a key regulator of protein and membrane transport in the early secretory pathway and the structure of the Golgi apparatus[3][5][8]. Although associated with some disease phenotypes such as cataracts, there is limited evidence for direct therapeutic targeting, interacting drugs, or use as a clinical biomarker[5].

Other names

ARF GTPase activating protein 1ARF1GAPARF GAP 1ARF1 GAPFLJ10767bA261N11.3ADP-ribosylation factor 1 GTPase-activating proteinARF1-directed GTPase-activating proteinHRIHFB2281