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Target intelligence / Profile preview
ADP-ribosylation factor GTPase-activating protein 3 (ARFGAP3)
- Target
- ARFGAP3
- Molecular classification
- Enzyme, GTPase-activating protein (GAP), Small GTPase regulatory protein
01
Overview
ADP-ribosylation factor GTPase-activating protein 3 (ARFGAP3) is an enzyme that acts as a GTPase-activating protein for ADP-ribosylation factor 1 (ARF1), a member of the small GTPase family involved in vesicle trafficking. ARFGAP3 is primarily associated with the Golgi apparatus, where it regulates the early secretory pathway of proteins by promoting hydrolysis of ARF1-bound GTP, leading to the dissociation of coat proteins from Golgi-derived membranes and vesicles. This dissociation enables the fusion of vesicles with target compartments. The activity of ARFGAP3 is sensitive to phospholipids, and multiple transcript variants exist, encoding different isoforms. The gene was previously confused with ARFGAP1, a different but related gene.
- Other names
- ARFGAP3ADP-ribosylation factor GTPase activating protein 3ARF GTPase activating protein 3FLJ10767LOC100045474
02
Biological functions
Regulation of vesicular trafficking (mainly early secretory pathway)Promotes GTP hydrolysis of ARF1Dissociation of coat proteins from Golgi/vesicular membranesRegulation of membrane fusion in the secretory pathwaySensitive to phospholipids
03
Disease associations
Autoimmune lymphoproliferative syndromeOther potential roles in membrane trafficking-related diseases
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