ADP-ribosylation factor-like 14 (ARL14)

ADP-ribosylation factor-like 14 (ARL14) is a small GTPase acting as a multifunctional regulator implicated in intracellular trafficking, vesicle-mediated transport, and disease progression[1][2]. ARL14’s N-terminal amphipathic helix directs its localization to endosomal and plasma membrane compartments. It is critical for antigen presentation by regulating the transport of MHC-II vesicles in dendritic cells and interacting with cytoskeletal motor proteins. Dysregulation of ARL14 is observed in several cancers, including non-small cell lung cancer and bladder cancer, where elevated expression is associated with poor prognosis and advanced tumor features, making it a candidate biomarker[1][3]. Studies also suggest ARL14 impacts cell cycle, migration, invasion, and apoptotic signaling, largely through ERK/p38 pathway modulation[3]. Functional genomics indicate low to no direct interaction with therapeutic drugs; most knowledge relates to its role as a disease biomarker and mechanistic target.

Other names

ARF7ADP-ribosylation factor 7ARL14_HUMANFLJ22595ADP-ribosylation factor-like protein 14

Not directly targeted by approved drugs; functional studies focus on RNAi (siRNA knockdown) reducing cancer cell proliferation and migration