ADP-ribosylation factor-like 16 pseudogene

ADP-ribosylation factor-like 16 pseudogene is a non-protein-coding genomic locus related to the ARL16 gene, which encodes a GTP-binding protein of the ADP-ribosylation factor-like family[4]. As a pseudogene, it harbors sequence similarity to its parent gene but has accumulated disabling mutations, preventing the production of a functional protein[2][5][7]. Pseudogenes may sometimes be transcribed and can play roles in the regulation of gene expression, but direct evidence for such function in the ARL16 pseudogene is lacking. It is not recognized as a therapeutic target, does not participate in canonical molecular pathways, and has no established biological or disease associations[2][5][7]. Pseudogenes are classified as unitary, unprocessed (duplicated), or processed pseudogenes by their genesis and structure[2][5]. The ARL16 protein (gene: ENSG00000214087), not the pseudogene, is a member of the ARF-like GTPases and has described cellular functions, but these do not apply to the pseudogene locus[4]. Catalogs of human pseudogenes, including ARF and ARL family members, exist but do not attribute functions, biomarkers, or druggability to the pseudogene entries[7]. This target is not a therapeutic target, nor is it a functional receptor, enzyme, or transporter. The submitted target is "incorrect" if the intended query is to find actionable drug targets or functional genes, as ARL16 pseudogene is nonfunctional and not druggable[2][5][7].

Other names

ARL16 pseudogene

None; pseudogenes do not encode active proteins or receptors for pharmacological targeting.