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Target intelligence / Profile preview
ADP-ribosylation factor-like GTPase 17A (ARL17A)
- Target
- ARL17A
- Molecular classification
- Small GTPase, GTP-binding protein, ADP-ribosylation factor-like protein, Intracellular transport protein
01
Overview
ADP-ribosylation factor-like GTPase 17A (ARL17A) is a small GTP-binding protein structurally related to the ADP-ribosylation factor family. It is predicted to function as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. ARL17A is involved in intracellular protein trafficking, with potential roles in vesicle budding and uncoating processes, especially within the Golgi apparatus. Its gene is located on chromosome 17. The protein is not currently established as a drug target, and there are no known interacting drugs or validated biomarker roles. Disease associations are noted with Koolen-De Vries syndrome and Glass syndrome, but ARL17A is not implicated as a direct driver or modulator in major human diseases[1][3][4][8][9].
- Other names
- ARL17AARL17P1ARF1P2PRO2667ADP-ribosylation factor-like protein 17ADP-ribosylation factor-like 17-likeADP-ribosylation factor 7 variantADP-ribosylation factor 7
02
Biological functions
Protein traffickingVesicle budding and uncoating in the Golgi apparatusIntracellular protein transportVesicle-mediated transport
03
Disease associations
Koolen-De Vries syndromeGlass syndrome (associations only, not a validated therapeutic target)
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