Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
ADP-ribosylation factor-like protein 5A (ARL5A)
- Target
- ARL5A
- Molecular classification
- Small GTPase, ARF family protein, GTP-binding protein, Other
01
Overview
ADP-ribosylation factor-like protein 5A (ARL5A) is a member of the ARF family of small GTP-binding proteins, structurally related to ADP-ribosylation factors but lacking their enzymatic activity. ARL5A is primarily localized to the nucleus/nucleolus, interacts with HP1alpha, and is developmentally regulated. It may play a role in nuclear and nucleolar dynamics or signaling cascades during embryonic development, although its precise cellular actions remain incompletely defined. Unlike canonical ARF proteins, ARL5A lacks ADP-ribosylation activity and its direct involvement in signaling, trafficking, or disease mechanisms is still under investigation. Disease associations include mucinous stomach adenocarcinoma and Dyggve-Melchior-Clausen disease, but no drugs or pharmacological modulators are currently reported for this target[3][6][7].
- Other names
- ADP-ribosylation factor like GTPase 5AARFLP5ARL5ADP-ribosylation factor-like 5AADP-ribosylation factor-like protein 5
02
Biological functions
Signal transductionInvolved in nuclear/nucleolar dynamicsPossible role in embryonic developmentGTP binding and hydrolysisOther
03
Disease associations
Cancer (notably mucinous stomach adenocarcinoma)Dyggve-Melchior-Clausen diseaseOther
Beyond the preview
Go deeper on ADP-ribosylation factor-like protein 5A (ARL5A).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on ADP-ribosylation factor-like protein 5A (ARL5A).