ADP-ribosylation factor-like protein 8A (ARL8A)

ADP-ribosylation factor-like protein 8A (ARL8A) is a member of the Ras small GTPase superfamily, primarily localized to lysosomal membranes, with a central role in regulating lysosome positioning and anterograde transport through the recruitment of specific adaptor proteins to kinesin motors. Its function is pivotal for processes such as antigen presentation, cytotoxic activity of natural killer cells, extracellular matrix degradation, and cancer cell invasion, as well as synaptic assembly and autophagy. Emerging studies also identify ARL8A as a clinical biomarker in certain cancers, and its associated gene (ARL8A) displays genetic links to Bardet-Biedl syndrome. While core interacting drugs or direct safety concerns are not established, its fundamental importance for lysosome-dependent cellular functions makes it a focus in cellular and disease research.

Other names

ARL10BGIE2FLJ45195Gie2ADP-ribosylation factor-like protein 10BNovel small G protein indispensable for equal chromosome segregation 2GTPase indispensable for equal segregation of chromosomes 2