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Adrenal Cortex Steroidogenesis Pathway
- Molecular classification
- Metabolic Pathway, Enzyme Cascade
01
Overview
The adrenal cortex steroidogenesis pathway is a complex series of enzymatic reactions within the adrenal cortex that convert cholesterol into steroid hormones, including glucocorticoids (cortisol), mineralocorticoids (aldosterone), and adrenal androgens (DHEA). The pathway is regulated by ACTH and angiotensin II, and defects in specific enzymes can cause various endocrine disorders.
- Other names
- Adrenal SteroidogenesisSteroid Hormone Biosynthesis (Adrenal Cortex)
02
Mechanism of action
Various, depending on the specific enzyme targeted. Examples include inhibition of steroidogenic enzymes like CYP11A1, CYP17A1, CYP21A2, CYP11B1, CYP11B2, or HSD3B2.
03
Biological functions
Steroid hormone synthesisGlucocorticoid productionMineralocorticoid productionAndrogen productionStress response regulationSalt and water balanceSexual development/maturation
04
Disease associations
Congenital adrenal hyperplasiaAddison's diseaseHormonal imbalancesCushing's syndromeHyperaldosteronismAdrenal insufficiency
05
Safety considerations
Adrenal insufficiencyElectrolyte imbalancesHypertensionHypotensionVirilizationFeminizationDrug-drug interactions
06
Interacting drugs
Ketoconazole
6 more in the full profile.
07
Biomarkers
Cortisol levelsAldosterone levelsDHEA/DHEAS levelsACTH levelsPregnenolone levels17-hydroxyprogesterone levelsAndrostenedione levels
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