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Adrenergic α₁A Receptor
- Molecular classification
- G protein-coupled receptor
01
Overview
The Adrenergic α₁A Receptor (ADRA1A) is a G protein-coupled receptor that primarily responds to adrenaline and noradrenaline. It mediates smooth muscle contraction in various tissues, including blood vessels, urethral sphincter, and iris dilator muscle. It also plays a role in cognitive function and neurotransmission within the central nervous system. Drugs targeting this receptor are used to treat hypertension and benign prostatic hyperplasia.
- Other names
- Alpha-1A adrenergic receptorα1A adrenoreceptorADRA1AAlpha-1C adrenergic receptor (historical; now obsolete)
02
Mechanism of action
Agonist-induced activation of Gq/11 proteins, leading to activation of phospholipase C (PLC) and increased intracellular calcium levels; Antagonist-induced blockade of receptor activation
03
Biological functions
Smooth muscle contractionVasoconstrictionUrethral sphincter contractionIris dilator muscle contractionEjaculationCognitive functionNeurotransmission regulationSignal transduction
04
Disease associations
HypertensionBenign prostatic hyperplasia
05
Safety considerations
Potential cardiovascular side effects with non-selective alpha-adrenergic antagonistsOrthostatic hypotension
06
Interacting drugs
Adrenaline (epinephrine)
4 more in the full profile.
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