Adrenergic alpha₂-C receptor (None)

The adrenergic alpha2C receptor (ADRA2C) is a G protein-coupled receptor (GPCR) that plays a key role in regulating neurotransmitter release from sympathetic nerves and central nervous system adrenergic neurons. It is primarily involved in the inhibition of adenylate cyclase, leading to decreased cAMP levels within cells. The alpha 2C subtype modulates neurotransmission at lower levels of nerve activity due to its higher affinity for norepinephrine and slower deactivation kinetics. High expression or altered function has been associated with pathogenesis such as preeclampsia and fetal growth restriction. Its broad CNS distribution suggests roles at multiple brain levels relevant for neuropsychiatric research.

Other names

ADRA2CADRA2L2ADRA2RL2Alpha-2 adrenergic receptor subtype C4Alpha-2C adrenoceptorAlpha-2CAR

Agonist or antagonist binding to the receptor, modulating downstream signaling pathways such as adenylate cyclase inhibition via Gi/o proteins.