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Target intelligence / Profile preview
Adrenergic alpha-1A receptor (ADRA1A)
- Target
- ADRA1A
- Molecular classification
- G protein-coupled receptor, GPCR, Receptor
01
Overview
The adrenergic alpha1A receptor (ADRA1A) is a G protein-coupled receptor that mediates various physiological responses including vasoconstriction and smooth muscle contraction. It is a target for drugs used to treat benign prostatic hyperplasia, such as tamsulosin. Emerging evidence suggests potential cardioprotective roles under specific conditions.
- Other names
- alpha1A-adrenoreceptorα1A-adrenoreceptoralpha-1C adrenergic receptor (historical)ADRA1A receptor
02
Mechanism of action
Antagonism (e.g., Tamsulosin) of the ADRA1A receptor leading to smooth muscle relaxation in the lower urinary tract.
03
Biological functions
VasoconstrictionSmooth muscle contractionSignal transductionNeurotransmissionRegulation of sympathetic outflowCardiac contractility modulation
04
Disease associations
Benign prostatic hyperplasiaCardiovascular disease (potential cardioprotective role under specific conditions)Urinary incontinence
05
Safety considerations
Potential for off-target effects due to receptor promiscuityCardiovascular side effects (e.g., orthostatic hypotension) with non-selective alpha-1 antagonists
06
Interacting drugs
Norepinephrine
2 more in the full profile.
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