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Target intelligence / Profile preview
Adrenergic alpha-1B receptor (ADRA1B)
- Target
- ADRA1B
- Molecular classification
- G protein-coupled receptor, GPCR
01
Overview
The adrenergic alpha-1B receptor (ADRA1B) is a subtype of the alpha-1 adrenergic receptors, a G protein-coupled receptor (GPCR) encoded by the ADRA1B gene. It plays a critical role in sympathetically mediated vasoconstriction, smooth muscle contraction, and cardiac function. Overexpression of ADRA1B can induce neoplastic transformation, identifying it as a proto-oncogene. It's also involved in baroreceptor-mediated cardiovascular responses and may have implications for treating orthostatic intolerance.
- Other names
- Alpha-1B adrenergic receptorα1B-adrenoreceptor
02
Mechanism of action
Gq/11 protein activation, leading to activation of phosphatidylinositol-calcium second messenger systems. Activation by norepinephrine leads to smooth muscle contraction primarily via vasoconstriction.
03
Biological functions
VasoconstrictionSmooth muscle contractionCardiac effectsCell growthCell proliferationSignal transduction
04
Disease associations
Cardiovascular diseaseOrthostatic intoleranceCancer
05
Safety considerations
Potential for neoplastic transformation when overexpressed
06
Interacting drugs
Cyclazosin
3 more in the full profile.
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