Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Adrenergic Alpha-1D Receptor (ADRA1D)
- Target
- ADRA1D
- Molecular classification
- G protein-coupled receptor, Receptor
01
Overview
The adrenergic alpha-1D receptor (ADRA1D) is a key regulator of vascular tone via sympathetic-mediated vasoconstriction. It acts mainly through calcium-dependent pathways following activation by endogenous catecholamines such as norepinephrine. Its predominant expression on blood vessels makes it an attractive target for research into cardiovascular diseases like hypertension.
- Other names
- Alpha1D adrenoreceptor
02
Mechanism of action
Activation of Gq/11 proteins, leading to stimulation of phospholipase C and increased intracellular calcium influx.
03
Biological functions
Signal transductionVasoconstrictionRegulation of blood pressurePhospholipase C activationPositive regulation of MAPK cascadeAdenylate cyclase-modulating GPCR signaling
04
Disease associations
HypertensionCardiovascular disease
05
Safety considerations
Non-selective alpha-adrenergic receptor antagonists may have off-target effects.
06
Interacting drugs
A-315456
3 more in the full profile.
Beyond the preview
Go deeper on Adrenergic Alpha-1D Receptor (ADRA1D).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Adrenergic Alpha-1D Receptor (ADRA1D).