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Target intelligence / Profile preview
Adrenergic alpha 2B receptor (α2B-adrenoceptor)
- Target
- α2B-adrenoceptor
- Molecular classification
- G protein-coupled receptor, Receptor
01
Overview
The adrenergic alpha 2B receptor (α2B-adrenoceptor) is a G protein-coupled receptor and one of three highly homologous subtypes in the alpha-2 adrenergic receptor family. It is found predominantly on vascular smooth muscle but also in kidney, brain, and spinal cord tissues. Activation leads to vasoconstriction and inhibition of neurotransmitter release. A deletion variant lacking three glutamic acids is associated with decreased phosphorylation/desensitization, reduced basal metabolic rate, and altered emotional memory.
- Other names
- ADRA2BADA2BAdra-2bAdra2balpha-2BARsubtype alpha2-C2
02
Mechanism of action
Inhibition of adenylyl cyclase activity via G proteins
03
Biological functions
Signal transductionVasoconstrictionInhibition of neurotransmitter release
04
Disease associations
ObesityCardiovascular disease
05
Interacting drugs
Clonidine
19 more in the full profile.
06
Biomarkers
ADRA2B deletion variant (glutamic acid repeat)
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