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Target intelligence / Profile preview
Adrenergic alpha 2C receptor (α2C adrenoceptor)
- Target
- α2C adrenoceptor
- Molecular classification
- G protein-coupled receptor (GPCR), Rhodopsin-like GPCR family, Receptor
01
Overview
The Adrenergic alpha 2C receptor (α2C adrenoceptor or ADRA2C) is a member of the G protein-coupled receptor (GPCR) superfamily. It regulates neurotransmitter release, insulin secretion, MAPK cascade, smooth muscle contraction, and vasoconstriction. It inhibits adenylate cyclase via Gi/o proteins. Located in the CNS and periphery, it plays a role in presynaptic inhibition and responds to catecholamines like norepinephrine and dopamine.
- Other names
- ADRA2CADRA2L2ADRA2RL2Alpha-2 adrenergic receptor subtype C4Alpha-2CAR
02
Mechanism of action
Inhibition of adenylate cyclase via Gi/o proteins, leading to decreased cAMP levels.
03
Biological functions
Regulation of neurotransmitter releaseNegative regulation of insulin secretionPositive regulation of MAPK cascadeRegulation of smooth muscle contractionVasoconstrictionInhibition of adenylate cyclaseG protein-coupled receptor signaling
04
Interacting drugs
(R)-3-Nitrobiphenyline
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