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Target intelligence / Profile preview
Adrenergic Beta-3 Receptor (ADRB3)
- Target
- ADRB3
- Molecular classification
- G protein-coupled receptor, GPCR, Class A rhodopsin-type GPCR, Receptor
01
Overview
The Adrenergic Beta-3 Receptor (ADRB3) is a G protein-coupled receptor primarily expressed in adipose tissue, gallbladder, and urinary bladder. It plays a key role in regulating lipolysis, thermogenesis, and bladder relaxation. ADRB3 variants have been associated with increased risk for obesity and diabetes. Agonists like mirabegron are used to treat overactive bladder.
- Other names
- Beta-3 adrenergic receptorβ₃-adrenoceptor
02
Mechanism of action
Catecholamine-induced activation leading to stimulation of adenylate cyclase through Gs proteins, increasing cyclic AMP levels.
03
Biological functions
Regulation of lipolysisThermogenesisBladder relaxationSignal transduction
04
Disease associations
ObesityNon-insulin-dependent diabetes mellitusOveractive bladderMetabolic disorders
05
Safety considerations
Potential cardiovascular effects (though less pronounced than with other beta-adrenergic receptors)Off-target effects of some ligands (e.g., SR59230A also blocks α₁ receptors)
06
Interacting drugs
Mirabegron
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