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Target intelligence / Profile preview
Adrenergic receptor alpha_2B (α2B adrenoceptor)
- Target
- α2B adrenoceptor
- Molecular classification
- G protein-coupled receptor, Receptor
01
Overview
The adrenergic receptor alpha_2B is a G protein-coupled receptor and one of three highly homologous subtypes in the alpha-2 adrenergic receptor family. It is found predominantly on vascular smooth muscle where it mediates vasopressor effects such as vasoconstriction and blood pressure regulation. A common deletion variant lacking three glutamic acids has been linked to reduced basal metabolic rate in obese individuals and enhanced emotional memory formation.
- Other names
- ADA2BAdrenergic alpha2B-receptor class IIIAdrenergic, alpha-2B-, receptorAlpha-2BARSubtype alpha2-C2
02
Mechanism of action
Agonists activate the receptor, inhibiting adenylyl cyclase and reducing cyclic AMP levels. This leads to hyperpolarization of noradrenergic neurons, suppressing neural firing and norepinephrine release.
03
Biological functions
Signal transductionRegulation of neurotransmitter releaseVasoconstrictionBlood pressure regulationInhibition of adenylate cyclaseRegulation of cyclic AMP levels
04
Disease associations
ObesityCardiovascular disease
05
Interacting drugs
Dexmedetomidine
2 more in the full profile.
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