Target intelligence / Profile preview

Adrenergic System (N/A)

Target
N/A
Molecular classification
G protein-coupled receptor, Receptor
01

Overview

The adrenergic system is a regulatory component of the autonomic nervous system that uses the neurotransmitters epinephrine (adrenaline) and norepinephrine (noradrenaline) to mediate neural and endocrine functions throughout the body. This system plays a central role in controlling cardiovascular, respiratory, metabolic, and other physiological processes by acting through specific cell surface receptors known as adrenergic receptors. These receptors are primarily divided into two main classes—alpha (α) and beta (β)—with further subtypes within each class: Alpha-1 (α1), Alpha-2 (α2), Beta-1 (β1), Beta-2 (β2), and Beta-3 (β3). Each subtype has distinct tissue distributions and physiological roles.

Other names
Adrenergic receptorsAdrenoreceptorsSympathoadrenal system
02

Mechanism of action

Agonism or antagonism of adrenergic receptors, modulating downstream signaling pathways.

03

Biological functions

Signal transductionCardiovascular regulationRespiratory regulationMetabolic regulationNeuromodulation
04

Disease associations

HypertensionHeart failureAsthmaAnxiety disordersDepressionCardiovascular disease
05

Safety considerations

Cardiovascular side effects (e.g., arrhythmias, hypotension)Bronchospasm (with beta-blockers in susceptible individuals)Central nervous system effects (e.g., anxiety, insomnia)
06

Interacting drugs

Epinephrine

5 more in the full profile.

07

Biomarkers

Plasma catecholamine levelsAdrenergic receptor polymorphisms

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