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Target intelligence / Profile preview
Adrenoceptor Alpha 2C (ADRA2C)
- Target
- ADRA2C
- Molecular classification
- G protein-coupled receptor, Receptor
01
Overview
The adrenergic receptor alpha-2C (ADRA2C) is a G protein-coupled receptor (GPCR) that belongs to the alpha-2 adrenergic receptor family. It regulates neurotransmitter release and mediates catecholamine-induced inhibition of adenylate cyclase. ADRA2C plays roles in cardiovascular regulation and has implications for neuropsychiatric disorders.
02
Mechanism of action
Catecholamine-induced inhibition of adenylate cyclase via G proteins, leading to decreased cAMP levels within cells; modulation of neurotransmitter release; vasoconstriction.
03
Biological functions
Signal transductionRegulation of neurotransmitter releaseInhibition of adenylate cyclase
04
Disease associations
Cardiovascular diseaseNeuropsychiatric disorders
05
Safety considerations
Potential for cardiovascular side effects due to vasoconstriction modulation.Implications for neuropsychiatric disorders require careful consideration in drug development.
06
Interacting drugs
BMY 7378
11 more in the full profile.
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