Adrenomedullin Receptor (ADMR)

The adrenomedullin receptor (ADMR) is a G protein-coupled receptor (GPCR) complex that mediates the biological effects of the peptide hormone adrenomedullin (AM). It plays critical roles in cardiovascular regulation, vascular development, metabolism, and inflammatory responses. The functional ADMR is a heterodimer composed of Calcitonin receptor-like receptor (CALCRL, also known as CLR) and Receptor activity-modifying proteins (RAMP2 or RAMP3), forming the AM1 and AM2 receptors, respectively. Upon ligand binding, ADMR activates intracellular signaling cascades primarily through increased cyclic AMP (cAMP) production. Therapeutic targeting of ADMR is being explored for conditions like heart failure/myocardial infarction due to its protective cardiovascular effects. In oncology research settings, inhibition or modulation of ADMR may offer new strategies for treating certain cancers.

Other names

CLR-RAMP ComplexAM1 receptorAM2 receptor

Activation of intracellular signaling cascades primarily through increased cyclic AMP (cAMP) production, leading to downstream activation of protein kinase A (PKA), exchange factor EPAC/Rap1, PI3K/Akt pathway, among others. These pathways regulate endothelial barrier function by modulating cytoskeletal dynamics and cell junction stability.