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Target intelligence / Profile preview
Adropin (ENHO)
- Target
- ENHO
- Molecular classification
- Peptide hormone, Hepatokine
01
Overview
Adropin is a 76-amino acid peptide hormone encoded by the energy homeostasis-associated gene (ENHO). It is primarily secreted by the liver and plays a crucial role in regulating metabolic homeostasis, cardiovascular function, immune regulation, and neurological function. Its expression is influenced by dietary intake and is associated with various clinical conditions, making it a promising target for therapeutic interventions.
- Other names
- Energy homeostasis-associated peptide
02
Mechanism of action
Adropin functions through multiple signaling pathways including the VEGFR2/PI3K/AKT, VEGFR2/ERK1/2, ROCK/MLC2, JAK2/STAT3, and AMPK pathways to regulate various physiological processes.
03
Biological functions
Glucose metabolism regulationLipid metabolism regulationInsulin sensitivity regulationEndothelial function regulationNitric oxide productionVascular protectionImmune regulationNeurological function regulationCircadian rhythm regulationReproductive system regulation
04
Disease associations
Cardiovascular diseasesMetabolic disordersObesityInsulin resistanceDyslipidemiaNon-alcoholic Fatty Liver Disease (NAFLD)Diabetic Kidney DiseaseStroke
05
Biomarkers
Adropin levels as a biomarker for cardiovascular disease riskAdropin levels as a biomarker for metabolic disorders
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