Adsorption of toxins and drugs in the gastrointestinal tract

This target refers to the process by which toxins and drugs, when present in the gastrointestinal tract, are prevented from being absorbed into the bloodstream through their physical adsorption onto administered agents such as activated charcoal or resins. This is a common therapeutic mechanism in cases of oral poisoning or overdose, where the aim is to decrease the bioavailability of harmful substances. The adsorption process is a physicochemical phenomenon, not mediated by specific biological receptors or enzymes[1][2][3][4][5]. The implementation relies on substances with high surface area and affinity for toxins, administered orally, to bind and prevent GI absorption, ultimately leading to fecal excretion.

Other names

Gastrointestinal adsorptionIntestinal adsorptionGI tract adsorption

Physical adsorption onto solid phase materials in the GI lumen, preventing systemic absorption and promoting elimination[1][2][3][5]